• Biology, Medicine
  • Published in Journal of immunology 1975

Strain differences in ease of tolerance induction to bovine gamma-globulin: dependence on macrophage function.

@article{Lukic1975StrainDI,
  title={Strain differences in ease of tolerance induction to bovine gamma-globulin: dependence on macrophage function.},
  author={Miodrag L Lukic and Carol Cowing and Sidney S. Leskowitz},
  journal={Journal of immunology},
  year={1975},
  volume={114 1 Pt 2},
  pages={
          503-6
        }
}
DBA/2 mice are highly susceptible while BALB/c mice are resistant to the induction of tolerance with ultracentrifuged BGG. As measured by the clearance of a test dose of 125-I-BGG, 2 mg ultracentrifuged BGG is sufficient to induce complete tolerance in DBA/2 mice, while BALB/c mice exhibit a clearance rate similar to immune controls. BALB/c mice pretreated with carrageenan (a macrophage toxic agent) lose their resistance to tolerance induction with 2 mg ultracentrifuged BGG, while treatment… CONTINUE READING