Strain differences in carcinogenic and hematopoietic responses of mice after injection of plutonium citrate.

@article{Oghiso2000StrainDI,
  title={Strain differences in carcinogenic and hematopoietic responses of mice after injection of plutonium citrate.},
  author={Yoichi Oghiso and Yutaka Yamada},
  journal={Radiation research},
  year={2000},
  volume={154 4},
  pages={447-54}
}
The carcinogenicity of injected (239)Pu citrate was compared in female mice of the C3H, C57BL/6 and BC3F(1) hybrid strains with different spectra of spontaneous or radiation-induced tumors. A significant reduction in survival due to early death caused particularly by the induction of osteosarcomas was noted in each strain after injection of 500 Bq or more. The dose response of osteosarcomas appeared to have a similar pattern in each strain except for the differences in the skeletal dose ranges… CONTINUE READING