Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intake.

@article{Kapasova2008StrainDI,
  title={Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intake.},
  author={Zuzana Kapasova and K K Szumlinski},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 4},
  pages={617-31}
}
BACKGROUND Repeated alcohol administration alters nucleus accumbens (NAC) basal glutamate content and sensitizes the capacity of alcohol to increase NAC extracellular glutamate levels. However, the relevance of alcohol-induced changes in NAC glutamate for alcohol drinking behavior is under-investigated. METHODS To examine the relationship between genetic variance in alcohol consumption and alcohol-induced neuroadaptations within the NAC, in vivo microdialysis was conducted in the alcohol… CONTINUE READING