Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae.

@article{Schricker1995StraindependentOO,
  title={Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae.},
  author={Roland Schricker and Viktor Magdolen and Gertrud Strobel and Edith Bogengruber and Michael Breitenbach and Wolfhard Bandlow},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 52},
  pages={
          31103-10
        }
}
The gene for yeast GTP:AMP phosphotransferase (PAK3) was found to encode a nonfunctional protein in 10 laboratory strains and one brewers' strain. The protein product showed high similarity to vertebrate AK3 and was located exclusively in the mitochondrial matrix. The deduced amino acid sequence revealed a protein that was shorter at the carboxyl terminus than all other known adenylate kinases. Introduction of a +1 frameshift into the 3'-terminal region of the gene extended homology of the… CONTINUE READING

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