Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice

@article{Castellano1993StraindependentEO,
  title={Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice},
  author={Claudio Castellano and Vincenzo Cestari and Simona Cabib and Stefano Puglisi-Allegra},
  journal={Psychopharmacology},
  year={1993},
  volume={111},
  pages={134-138}
}
Post-training administration of the GABA-A and GABA-B receptor agonists muscimol and baclofen dose-dependently impaired retention of an inhibitory avoidance response in C57 mice, while improving memory consolidation in the DBA strain. By contrast, picrotoxin (blocker of GABA-activated ionophores), bicuculline (GABA-A antagonist) and CGP 35348 (GABA-B antagonist) dose-dependently improved retention in C57 mice and impaired it in DBA mice. These effects cannot be ascribed to non-specific actions… CONTINUE READING

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Gabaergic modulation of memory In: Squire L, Lindelaub E (eds) Biology of memory

  • C Castellano, JD Brioni, JL McGaugh
  • 1990

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