Strain-dependent behavioural sensitization to amphetamine: role of environmental influences.

  title={Strain-dependent behavioural sensitization to amphetamine: role of environmental influences.},
  author={Simona Cabib},
  journal={Behavioural pharmacology},
  volume={4 4},
Repeated daily pairings of 1mg/kg of amphetamine and test environment induced a large, significant increase of locomotion in mice of the C57BL/6 strain, while a slight, non-significant increase was observed in mice of the DBA/2 strain. Neither C57BL/6 nor DBA/2 mice showed behavioral sensitization to amphetamine in the test cages when the drug was repeatedly administered in their home cage. Moreover, C57BL/6 but not DBA/2 mice showed conditioned hyperactivity. Subsequently six daily pairings of… CONTINUE READING

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