Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice.

@article{ZuanyAmorim1994StraindependencyOL,
  title={Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice.},
  author={Claudia Zuany-Amorim and Bernardo Boris Vargaftig and Jacques Maclouf and Marina Pretolani},
  journal={British journal of pharmacology},
  year={1994},
  volume={112 4},
  pages={1230-6}
}
1. The antigen-induced leukotriene C4 (LTC4)-like-material release from isolated perfused lungs of actively sensitized Swiss, Balb/C and CBA/J mice was compared. The intra-tracheal (i.t.) instillation of 1 and 100 micrograms ovalbumin to lungs from Swiss mice was followed by a dose-dependent generation of LTC4-like material into the effluent, as detected by radio-immunoassay and h.p.l.c., followed by an enzyme-immunoassay. In contrast, lungs from sensitized Balb/C and CBA/J mice failed to… CONTINUE READING