Strain and sex variation in the susceptibility to streptococcal cell wall-induced polyarthritis in the rat.

@article{Wilder1982StrainAS,
  title={Strain and sex variation in the susceptibility to streptococcal cell wall-induced polyarthritis in the rat.},
  author={R. LawrenceDr. Wilder and Gary B. Calandra and Abbott Julian Garvin and Kenneth D. Wright and Carl T. Hansen},
  journal={Arthritis and rheumatism},
  year={1982},
  volume={25 9},
  pages={
          1064-72
        }
}
Sixteen inbred rat strains were examined for susceptibility and resistance to group A streptococcal cell wall-induced polyarthritis. The findings indicated that 2 or more genetic loci, as well as sex-related factors, played a major role in determining susceptibility to arthritis in this model. Breeding studies demonstrated that susceptibility was a dominant or codominant trait. A positive association between the severity of arthritis and the development of chronic inflammation in multiple… CONTINUE READING
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