Strain and schedule-dependent differences in the acquisition, maintenance and extinction of intravenous cannabinoid self-administration in rats

@article{Deiana2007StrainAS,
  title={Strain and schedule-dependent differences in the acquisition, maintenance and extinction of intravenous cannabinoid self-administration in rats},
  author={Serena Deiana and L Fattore and Maria Sabrina Spano and Gregorio Cossu and Walter Fratta},
  journal={Neuropharmacology},
  year={2007},
  volume={52},
  pages={646-654}
}
Cannabinoids have been reported to sustain self-administration in laboratory animals; however, genetic differences and environmental factors critical in the initiation and retention of such behaviour are yet to be defined. This study investigated the acquisition, maintenance and extinction of self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 (6.25-25 microg/kg/inf) in Long Evans, Lister Hooded and Sprague-Dawley rats under a continuous schedule of reinforcement and two… CONTINUE READING
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