Strain-adaptive in silico modeling of bone adaptation--a computer simulation validated by in vivo micro-computed tomography data.

@article{Schulte2013StrainadaptiveIS,
  title={Strain-adaptive in silico modeling of bone adaptation--a computer simulation validated by in vivo micro-computed tomography data.},
  author={Friederike A. Schulte and Alexander Zwahlen and Floor M. Lambers and Gisela Kuhn and Davide Ruffoni and Duncan Colin Betts and Duncan James Webster and Ralph M{\"u}ller},
  journal={Bone},
  year={2013},
  volume={52 1},
  pages={485-92}
}
Computational models are an invaluable tool to test different mechanobiological theories and, if validated properly, for predicting changes in individuals over time. Concise validation of in silico models, however, has been a bottleneck in the past due to a lack of appropriate reference data. Here, we present a strain-adaptive in silico algorithm which is validated by means of experimental in vivo loading data as well as by an in vivo ovariectomy experiment in the mouse. The maximum prediction… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…