Strain activation of bovine aortic smooth muscle cell proliferation and alignment: study of strain dependency and the role of protein kinase A and C signaling pathways.

@article{Mills1997StrainAO,
  title={Strain activation of bovine aortic smooth muscle cell proliferation and alignment: study of strain dependency and the role of protein kinase A and C signaling pathways.},
  author={Ira Mills and Craig R Cohen and Kamran Kamal and Gui-Rong Li and Thomas H Shin and Wen ‐ Zhong Du and Bauer E. Sumpio},
  journal={Journal of cellular physiology},
  year={1997},
  volume={170 3},
  pages={228-34}
}
Smooth muscle cell (SMC) phenotype can be altered by physical forces as demonstrated by cyclic strain-induced changes in proliferation, orientation, and secretion of macromolecules. However, the magnitude of strain required and the intracellular coupling pathways remain ill defined. To examine the strain requirements for SMC proliferation, we selectively seeded bovine aortic SMC either on the center or periphery of silastic membranes which were deformed with 150 mm Hg vacuum (0-7% center; 7-24… CONTINUE READING
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