Straightforward synthesis of 7 alpha-methoxy-1-oxacephems from penicillins.

  • W. Nagata
  • Published 1980 in
    Philosophical transactions of the Royal Society…


A straightforward and industrially feasible synthesis of 7 beta-acylamino-7 alpha-methoxy-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]-1-oxa-3-cephem-4-carboxylic acid (35) from penicillins is described. Reaction of 6 alpha-acylaminopenicillanate S-oxides with triphenylphosphine gave epioxazolines (16) which were transformed into allylic alcohols (28) via… (More)


Cite this paper

@article{Nagata1980StraightforwardSO, title={Straightforward synthesis of 7 alpha-methoxy-1-oxacephems from penicillins.}, author={W. Nagata}, journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences}, year={1980}, volume={289 1036}, pages={225-30} }