Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120.

@article{Matz2013StraightforwardSO,
  title={Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120.},
  author={Julie Matz and Pascal Kessler and J{\'e}r{\^o}me Bouchet and Olivier Combes and Oscar Henrique Pereira Ramos and Francis Barin and Daniel Baty and Lo{\"i}c Martin and Serge B{\'e}nichou and Patrick Chames},
  journal={Journal of virology},
  year={2013},
  volume={87 2},
  pages={1137-49}
}
Few broadly neutralizing antibodies targeting determinants of the HIV-1 surface envelope glycoprotein (gp120) involved in sequential binding to host CD4 and chemokine receptors have been characterized. While these epitopes show low diversity among various isolates, HIV-1 employs many strategies to evade humoral immune response toward these sensitive sites, including a carbohydrate shield, low accessibility to these buried cavities, and conformational masking. Using trimeric gp140, free or bound… CONTINUE READING
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