Storm in a coffee cup: caffeine modifies brain activation to social signals of threat.

@article{Smith2012StormIA,
  title={Storm in a coffee cup: caffeine modifies brain activation to social signals of threat.},
  author={J. E. Smith and A. Lawrence and A. Diukova and R. Wise and P. Rogers},
  journal={Social cognitive and affective neuroscience},
  year={2012},
  volume={7 7},
  pages={
          831-40
        }
}
Caffeine, an adenosine A₁ and A(2A) receptor antagonist, is the most popular psychostimulant drug in the world, but it is also anxiogenic. The neural correlates of caffeine-induced anxiety are currently unknown. This study investigated the effects of caffeine on brain regions implicated in social threat processing and anxiety. Participants were 14 healthy male non/infrequent caffeine consumers. In a double-blind placebo-controlled crossover design, they underwent blood oxygenation level… Expand
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References

SHOWING 1-10 OF 83 REFERENCES
Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
TLDR
The data support the hypothesis that individual variation in threat sensitivity interacts with manipulation of 5-HT function to bias the processing of amygdala-dependent threat-relevant stimuli. Expand
Nicotine increases neural response to unpleasant stimuli and anxiety in non‐smokers
TLDR
A single dose of nicotine acted as a stressor in non‐smokers, leading to increased anxiety and neural activation elicited by unpleasant stimuli as well as altered connectivity within the amygdala–pACC circuit. Expand
Dietary Caffeine Consumption Modulates fMRI Measures
TLDR
It is proposed that the outcome observed here was due to an upregulation of adenosine receptors in high users, resulting in differential contributions of the neural and vascular effects ofAdenosine in the two study populations. Expand
State Anxiety Modulation of the Amygdala Response to Unattended Threat-Related Stimuli
TLDR
A functional magnetic resonance imaging study with 27 healthy volunteers to examine whether amygdala responsivity to unattended threat-related stimuli varies with individual differences in state anxiety suggests that anxiety may interact with attentional focus to determine the magnitude of the amygdala response to threat- related stimuli. Expand
Noradrenergic enhancement of amygdala responses to fear.
TLDR
Extrapolation of data to conditions of traumatic stress suggests that disinhibited endogenous NE signaling could serve as a crucial etiological contributor to post-traumatic stress disorder (PTSD) by eliciting exaggerated BLA responses to fear signals. Expand
Brain mediators of cardiovascular responses to social threat, Part II: Prefrontal-subcortical pathways and relationship with anxiety
TLDR
These data suggest pathways for the translation of social threats into both physiological and experiential responses, and provide targets for future research on the generation and regulation of emotion. Expand
Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together
TLDR
Evidence suggests that theanine is a physiologically and behaviourally active compound and, while it is unclear how its effects might explain perceived differences between tea and coffee, evidence suggests that it may be useful for reducing raised blood pressure. Expand
Mood and performance effects of caffeine in relation to acute and chronic caffeine deprivation
TLDR
It would appear that to avoid the dysphoric symptoms resulting from both under- and overconsumption, regular caffeine consumers would have to regulate their caffeine intake fairly precisely. Expand
Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption
TLDR
Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype. Expand
Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli
TLDR
It is found that rostral ACC was strongly activated by infrequent threat-related distractors, consistent with a role for this area in responding to unexpected processing conflict caused by salient emotional stimuli and supports the proposal that anxiety is associated with reduced top-down control over threat- related distractors. Expand
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