Stored red blood cells selectively activate human neutrophils to release IL-8 and secretory PLA2.

@article{Zallen2000StoredRB,
  title={Stored red blood cells selectively activate human neutrophils to release IL-8 and secretory PLA2.},
  author={Garret Zallen and Ernest Eugene Moore and David J. Ciesla and Margaret Brown and Walter L. Biffl and Christopher C. Silliman},
  journal={Shock},
  year={2000},
  volume={13 1},
  pages={29-33}
}
Packed red blood cell (PRBC) transfusion has been invoked previously with immunosuppression and increased infections, but it has now been demonstrated that stored PRBCs (>14 days) can prime PMNs and provoke multiple organ failure. Recently, the role of PMNs in the genesis of MOF has been extended to their release of inflammatory cytokines, notably IL-1, IL-8, TNFalpha, and secretory phospholipase A2 (sPLA2). We hypothesize that stored PRBCs can act as a second event via stimulating the release… CONTINUE READING

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