Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase

@inproceedings{Emeriau2018StoreOC,
  title={Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase},
  author={No{\'e}mie Emeriau and Marie de Clippele and Philippe Gailly and Nicolas Tajeddine},
  booktitle={Oncotarget},
  year={2018}
}
SOCE (Store-Operated Calcium Entry) is the main mechanism by which external Ca2+ enters into non-excitable cells after endoplasmic reticulum emptying. It is implicated in several processes such as proliferation and migration. Alterations in SOCE could initiate or support the development of hallmarks of cancer. In this project, we showed that disruption of the EGFR/ErbB2-dependent signalling by lapatinib and CP-724714, two inhibitors of the receptor tyrosine kinase (RTK), dramatically reduced… CONTINUE READING

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