Store-operated calcium entry induced by activation of Gq-coupled alpha1B adrenergic receptor in human osteoblast.

@article{Kodama2013StoreoperatedCE,
  title={Store-operated calcium entry induced by activation of Gq-coupled alpha1B adrenergic receptor in human osteoblast.},
  author={Daisuke Kodama and Akifumi Togari},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={437 2},
  pages={239-44}
}
Recent studies have revealed that the sympathetic nervous system is involved in bone metabolism. We previously reported that noradrenaline (NA) suppressed K(+) currents via Gi/o protein-coupled alpha1B-adrenergic receptor (α1B-AR) in human osteoblast SaM-1 cells. Additionally, it has been demonstrated that the intracellular Ca(2+) level ([Ca(2+)]i) was… CONTINUE READING