Store-operated Orai channels: structure and function.

  title={Store-operated Orai channels: structure and function.},
  author={Murali Prakriya},
  journal={Current topics in membranes},
In many animal cells, store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels function as an essential route for Ca(2+) entry. CRAC channels control many fundamental cellular functions including gene expression, motility, and cell proliferation, are involved in the etiology of several disease processes including a severe combined immunodeficiency syndrome, and have emerged as major targets for drug development. Although little was known of the molecular mechanisms of CRAC channel… CONTINUE READING


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