Store-operated Ca2+ entry in muscle physiology and diseases

  title={Store-operated Ca2+ entry in muscle physiology and diseases},
  author={Zui Pan and Marco Brotto and Jianjie Ma},
  booktitle={BMB reports},
Ca(2+) release from intracellular stores and influx from extracellular reservoir regulate a wide range of physiological functions including muscle contraction and rhythmic heartbeat. One of the most ubiquitous pathways involved in controlled Ca(2+) influx into cells is store-operated Ca(2+) entry (SOCE), which is activated by the reduction of Ca(2+) concentration in the lumen of endoplasmic or sarcoplasmic reticulum (ER/SR). Although SOCE is pronounced in non-excitable cells, accumulating… CONTINUE READING

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