Store-operated Ca2+ entry activates the CREB transcription factor in vascular smooth muscle.

@article{Pulver2004StoreoperatedCE,
  title={Store-operated Ca2+ entry activates the CREB transcription factor in vascular smooth muscle.},
  author={Renee A. Pulver and Patricia Rose-Curtis and Michael W. Roe and George C. Wellman and Karen M. Lounsbury},
  journal={Circulation research},
  year={2004},
  volume={94 10},
  pages={1351-8}
}
Ca2+-regulated gene transcription is a critical component of arterial responses to injury, hypertension, and tumor-stimulated angiogenesis. The Ca2+/cAMP response element binding protein (CREB), a transcription factor that regulates expression of many genes, is activated by Ca2+-induced phosphorylation. Multiple Ca2+ entry pathways may contribute to CREB activation in vascular smooth muscle including voltage-dependent Ca2+ channels and store-operated Ca2+ entry (SOCE). To investigate a role for… CONTINUE READING

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