Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1.

@article{Bandyopadhyay2011StoreoperatedCS,
  title={Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1.},
  author={Bidhan C. Bandyopadhyay and Sandeep C. Pingle and Gerard P. Ahern},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={89 1},
  pages={57-62}
}
SOCE via CRAC channels is a critical signaling event in immune cells. Recent studies have identified key proteins underlying this process; STIM is an ER Ca²+ sensor that interacts with Orai, an intrinsic, pore-forming protein of the CRAC channel. In heterologous expression systems, STIM1 regulates SOCE by interacting with Orai1, -2, and -3. In native tissues, however, the precise roles of STIM and Orai proteins are not well defined. Here, we have investigated the molecular components of SOCE… CONTINUE READING