Store-operated CRAC channels: function in health and disease

  title={Store-operated CRAC channels: function in health and disease},
  author={Anant B Parekh},
  journal={Nature Reviews Drug Discovery},
  • A. Parekh
  • Published 1 May 2010
  • Biology, Medicine
  • Nature Reviews Drug Discovery
Elevation of cytosolic Ca2+ levels through the activation of store-operated Ca2+ release-activated Ca2+ (CRAC) channels is involved in mediating a disparate array of cellular responses. These include secretion, metabolism and gene expression, as well as cell growth and proliferation. Moreover, emerging evidence points to the involvement of aberrant CRAC channel activity in human diseases, such as certain types of immunodeficiency and autoimmunity disorders, allergy, and inflammatory bowel… 

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STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

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  • S. Feske
  • Biology
    Immunological reviews
  • 2009
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