Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

@article{GonzlezCobos2013StoreindependentOC,
  title={Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.},
  author={Jos{\'e} C. Gonz{\'a}lez-Cobos and Xuexin Zhang and Wei Zhang and Brian Ruhle and Rajender K Motiani and Rainer Schindl and Martin Muik and Amy M. Spinelli and Jonathan M. Bisaillon and Arti V. Shinde and Marc Fahrner and Harold A. Singer and Khalid Matrougui and Margarida Barroso and Christoph Romanin and Mohamed Trebak},
  journal={Circulation research},
  year={2013},
  volume={112 7},
  pages={1013-25}
}
RATIONALE Through largely unknown mechanisms, Ca(2+) signaling plays important roles in vascular smooth muscle cell (VSMC) remodeling. Orai1-encoded store-operated Ca(2+) entry has recently emerged as an important player in VSMC remodeling. However, the role of the exclusively mammalian Orai3 protein in native VSMC Ca(2+) entry pathways, its upregulation during VSMC remodeling, and its contribution to neointima formation remain unknown. OBJECTIVE The goal of this study was to determine the… CONTINUE READING
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