Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels.

@article{Molnr2016StoreOperatedCE,
  title={Store-Operated Calcium Entry in M{\"u}ller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels.},
  author={T{\"u}nde Moln{\'a}r and Oleg Yarishkin and Anthony Iuso and Peter Barabas and Bryan W. Jones and Robert E. Marc and Tam Thi Thanh Phuong and David Kri{\vz}aj},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016},
  volume={36 11},
  pages={
          3184-98
        }
}
UNLABELLED The endoplasmic reticulum (ER) is at the epicenter of astrocyte Ca(2+) signaling. We sought to identify the molecular mechanism underlying store-operated calcium entry that replenishes ER stores in mouse Müller cells. Store depletion, induced through blockade of sequestration transporters in Ca(2+)-free saline, induced synergistic activation of canonical transient receptor potential 1 (TRPC1) and Orai channels. Store-operated TRPC1 channels were identified by their… CONTINUE READING

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