Storage of strain-specific rat blood limits cerebral tissue oxygen delivery during acute fluid resuscitation.

@article{Rigamonti2008StorageOS,
  title={Storage of strain-specific rat blood limits cerebral tissue oxygen delivery during acute fluid resuscitation.},
  author={Andrea Rigamonti and Anya T McLaren and Cyril David Mazer and Kimberley Nix and T Ragoonanan and Jenna Freedman and Amy Harrington and G. Hare},
  journal={British journal of anaesthesia},
  year={2008},
  volume={100 3},
  pages={357-64}
}
BACKGROUND The effect of blood storage on tissue oxygen delivery has not been clearly defined. Some studies demonstrate reduced microvascular oxygen delivery, whereas others do not. We hypothesize that storage of rat blood will limit its ability to deliver oxygen to cerebral tissue. METHODS Anaesthetized rats underwent haemorrhage (18 ml kg(-1)) and resuscitation with an equivalent amount of fresh or 7 day stored strain-specific whole blood. Arterial blood gases, co-oximetry, red cell counts… CONTINUE READING
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