Storage of Spatial Information by the Maintenance Mechanism of LTP

@article{Pastalkova2006StorageOS,
  title={Storage of Spatial Information by the Maintenance Mechanism of LTP},
  author={Eva Pastalkova and Peter A Serrano and Deana Pinkhasova and Emma J C Wallace and Andr{\'e} Antonio Fenton and Todd Charlton Sacktor},
  journal={Science},
  year={2006},
  volume={313},
  pages={1141 - 1144}
}
Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMz), has been found to maintain late LTP in… Expand
PKMζ, LTP Maintenance, and Long-Term Memory Storage
TLDR
This chapter reviews the current state of knowledge on PKMζ, focusing on its discovery and the elucidation of its unique structure as an autonomously active form of PKC, its function in LTP maintenance, and its role in normal memory storage and disorders of memory. Expand
PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage.
  • T. Sacktor
  • Chemistry, Medicine
  • Progress in brain research
  • 2008
How memories persist is a fundamental neurobiological question. The most commonly studied physiological model of memory is long-term potentiation (LTP). The molecular mechanisms of LTP can be dividedExpand
PKM z , LTP maintenance , and the dynamic molecular biology of memory storage
How memories persist is a fundamental neurobiological question. The most commonly studied physiological model of memory is long-term potentiation (LTP). The molecular mechanisms of LTP can be dividedExpand
Persistence of Long-Term Memory Storage: New Insights into its Molecular Signatures in the Hippocampus and Related Structures
TLDR
In rats, the protein translation inhibitor anisomycin impaired memory persistence when injected into the dorsal hippocampus 12 h after inhibitory avoidance (IA) training without affecting memory formation, and memory persistence is associated with a late phase of plasticity-related protein synthesis in the hippocampus. Expand
Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation
TLDR
The likelihood that each mechanism is necessary or sufficient to maintain memory is explored, with a simplified model incorporating persistent kinase activation, synaptic tagging, and preferential reactivation of strong synapses simulated. Expand
Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation
TLDR
A simplified model of LTP with a simplified model incorporating persistent kinase activation, synaptic tagging, and preferential reactivation of strong synapses suggested that synaptic reactivation and autonomous kinaseactivation could synergistically maintain LTP. Expand
A Model of Late Long-Term Potentiation Simulates Aspects of Memory Maintenance
TLDR
Simulations illustrated that prolonged periods of decreased activity reset synaptic strengths to low values, suggesting a plausible forgetting mechanism; however, episodic activity with shorter inactive intervals maintained strong synapses, and both models support experimental predictions. Expand
BDNF is essential to promote persistence of long-term memory storage
TLDR
It is demonstrated that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis, and induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner. Expand
LTP maintenance and its protein synthesis-dependence
TLDR
The case is still very strong for a necessary role of protein synthesis in LTP stabilization, even though the identities of the synthesized proteins and their contributions to the LTP process are not fully understood. Expand
Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage
TLDR
Examination of the amount and distribution of PKMζ in subregions of the hippocampal formation of wild-type mice during LTP maintenance and spatial long-term memory storage concludes that persistent increases in PKM ζ trace the molecular mechanism of LTP Maintenance and thus the sites of information storage within brain circuitry during long- term memory. Expand
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