Storage of Spatial Information by the Maintenance Mechanism of LTP

@article{Pastalkova2006StorageOS,
  title={Storage of Spatial Information by the Maintenance Mechanism of LTP},
  author={Eva Pastalkova and P. Serrano and Deana Pinkhasova and E. Wallace and A. Fenton and T. Sacktor},
  journal={Science},
  year={2006},
  volume={313},
  pages={1141 - 1144}
}
  • Eva Pastalkova, P. Serrano, +3 authors T. Sacktor
  • Published 2006
  • Medicine, Chemistry
  • Science
  • Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMz), has been found to maintain late LTP in… CONTINUE READING

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