Storage lesion: role of red blood cell breakdown.

@article{KimShapiro2011StorageLR,
  title={Storage lesion: role of red blood cell breakdown.},
  author={Daniel B. Kim-Shapiro and Janet S. Lee and Mark T Gladwin},
  journal={Transfusion},
  year={2011},
  volume={51 4},
  pages={844-51}
}
As stored blood ages intraerythrocytic energy sources are depleted resulting in reduced structural integrity of the membrane. Thus, stored red blood cells (RBCs) become less deformable and more fragile as they age. This fragility leads to release of cell-free hemoglobin (Hb) and formation of microparticles, submicron Hb-containing vesicles. Upon transfusion, it is likely that additional hemolysis and microparticle formation occurs due to breakdown of fragile RBCs. Release of cell-free Hb and… CONTINUE READING