Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccines.

@article{Boros2001StorageA,
  title={Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccines.},
  author={Christina A Boros and Mark Hanlon and Michael S Gold and Donal Muir Roberton},
  journal={Vaccine},
  year={2001},
  volume={19 25-26},
  pages={3537-42}
}
The immunogenicity of pertussis antigens in an acellular and a whole-cell triple antigen vaccine used for childhood immunisation was assessed in murine models after storage of vaccines below 0 degree C. Swiss outbred and Balb/c mice received DTPa or DTPw vaccine or placebo. Vaccines were stored at 2-8 degrees C (ideal), or at -3 degrees C for 24 h. Pre and post immunisation IgG responses to pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin (PRN) were measured using enzyme… CONTINUE READING
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