Storage and degradation of secretory proteins in adenomatous and secondary hyperplastic parathyroid cells

Parathyroid hormone (PTH) and chromogranin A/secretory protein-I (SP-I) have been localized on immunoelectron microscopy in double-fixed tissues from adenomatous and secondary hyperplastic parathyroid glands. Storage organelles, identified on the basis of their consistent labelling, included two morphologically distinct varieties of granules/vesicles; the… CONTINUE READING