Storage, expression and function of Fas ligand, the key death factor of immune cells.

@article{Lettau2008StorageEA,
  title={Storage, expression and function of Fas ligand, the key death factor of immune cells.},
  author={Marcus Lettau and Maren Paulsen and Dieter Kabelitz and Ottmar Janssen},
  journal={Current medicinal chemistry},
  year={2008},
  volume={15 17},
  pages={
          1684-96
        }
}
The TNF family member Fas ligand (FasL) induces apoptosis in Fas-expressing cells and serves as a key death factor in the immune system. It is involved in the termination of immune responses by activation-induced cell death, the selection of thymocytes and T and NK cell-mediated cytotoxicity. FasL also participates in the establishment of immune privilege and contributes to tumor cell survival. Besides its death-inducing capacity, FasL has been implicated in retrograde signal transduction into… CONTINUE READING
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Posttranslational regulation of Fas ligand function

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