Stopping clinical trials by design

@article{Whitehead2004StoppingCT,
  title={Stopping clinical trials by design},
  author={John Whitehead},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={973-977}
}
Before any clinical trial begins, a detailed trial protocol must be prepared. The authority of the trial results will depend on the quality of this document. In many protocols, a key component is a plan for a series of interim analyses of the accumulating trial data, and a 'stopping rule' based on them. Such a rule might be intended to prevent participants from continuing to receive a drug that already seems to be unsafe, or to allow a successful drug to become generally available as soon as… CONTINUE READING

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