Stopping a trial early in oncology: for patients or for industry?

@article{Bradbury2009StoppingAT,
  title={Stopping a trial early in oncology: for patients or for industry?},
  author={Penelope Ann Bradbury and Ralph Meyer and Joseph Pater and Dongsheng Tu and Lesley Seymour and Lois Shepherd and Elizabeth Eisenhauer},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2009},
  volume={20 2},
  pages={
          395-6
        }
}
We read the article by Trotta et al. [1] with interest and agree that reporting of randomized controlled trials (RCTs) before meeting protocol-defined criteria for conducting a final analysis is an important and complex issue. However, we differ from some of their conclusions. The authors analyzed 25 RCTs that were reported from 1997 to 2007 that were selected for review based on early stopping for benefit associated with experimental therapy. Two of the selected trials were conducted by the… CONTINUE READING
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