Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans

  title={Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans},
  author={Adam R. Aron and Paul C. Fletcher and Edward T. Bullmore and Barbara Jacquelyn Sahakian and Trevor William Robbins},
  journal={Nature Neuroscience},
The precise localization of executive functions such as response inhibition within the prefrontal cortex (PFC), although theoretically crucial, has proven to be controversial and difficult. Functional neuroimaging has contributed importantly to this debate, but as human cortical lesions are seldom discrete, the literature still lacks definitive neuropsychological evidence that a specific region is necessary for task performance. We overcame this limitation by using a new observer-independent… 

Causal Prefrontal Contributions to Stop-Signal Task Performance in Humans

It is suggested that multiple prefrontal regions make necessary but distinct contributions to stop-signal task performance as a consequence of focal prefrontal damage not strongly localizing within the frontal lobes.

Inhibition processes are dissociable and lateralized in human prefrontal cortex

Left inferior frontal gyrus is critical for response inhibition

It is indicated that the integrity of left IFG is also critical for successful implementation of inhibitory control over motor responses, and the findings demonstrate the importance of obtaining converging evidence from multiple methodologies in cognitive neuroscience.

Dissociable mechanisms of cognitive control in prefrontal and premotor cortex.

The observed double dissociation of neurodisruptive effects between the right IFG and right dPM implies that response inhibition and execution rely on distinct neural processes despite activating a common cortical network.

Right lateral prefrontal cortex--specificity for inhibition or strategy use?

This scientific commentary refers to ‘Verbal suppression and strategy use: a role for the right lateral prefrontal cortex?’, by Robinson et al. (doi:10.1093/brain/awv003), by investigating the specificity of PFC subregions for verbal initiation, suppression and Strategy use in a large cohort of lesion patients.

Assessing the effects of tDCS over a delayed response inhibition task by targeting the right inferior frontal gyrus and right dorsolateral prefrontal cortex

Transcranial direct current stimulation was delivered to 115 healthy subjects, using five stimulation setups that differed in terms of target area (rIFG or rDLPFC) and polarity of stimulation (anodal, cathODal, or sham).

Executive Brake Failure following Deactivation of Human Frontal Lobe

Using transcranial magnetic stimulation, it is found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action.



Right hemispheric dominance of inhibitory control: an event-related functional MRI study.

  • H. GaravanT. RossE. Stein
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
Normal human behavior and cognition are reliant on a person's ability to inhibit inappropriate thoughts, impulses, and actions. The temporal and spatial advantages of event-related functional MRI

Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI.

The results imply that the right inferior prefrontal area is commonly involved in the inhibition of different targets, i.e. the go response during performance of the go/no-go task and the cognitive set duringperformance of the WCST.

Error‐related brain activation during a Go/NoGo response inhibition task

Investigation of error‐related brain activity associated with failure to inhibit response during a Go/NoGo task provides evidence for a distributed error processing system in the human brain that overlaps partially, but not completely, with brain regions involved in response inhibition and competition.

Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI.

Functional magnetic resonance imaging was used to investigate the hypothesis that attention deficit hyperactivity disorder (ADHD) is associated with a dysfunction of prefrontal brain regions during motor response inhibition and motor timing, and hyperactive adolescents showed lower power of response.

The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive.

  • P. Goldman-Rakic
  • Psychology, Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1996
This paper focuses on the working memory processor as a specialization of prefrontal cortex and argues that the different areas within prefrontal cortex represent iterations of this function for different information domains, including spatial cognition, object cognition and additionally, in humans, semantic processing.

No‐go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging

The results suggest that this region in the prefrontal cortex is related to the neural mechanisms underlying the response inhibition function, and looked for the prefrontal areas in which the brain activity in no‐go trials is dominant over that in go trials.

Inhibitory Processes in Attention, Memory and Language

The Neurology of Inhibition: Integrating Controlled and Automatic Processes. A Model of Inhibitory Mechanisms in Selective Attention. Categories of Cognitive Inhibition, With Reference to Attention.

Spatial Normalization of Brain Images with Focal Lesions Using Cost Function Masking

The results suggest that cost-function masking is superior to the standard approach to this problem, which is affine-only normalization; it is proposed that it should be used routinely for normalizations of brains with focal lesions.