Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective.

@article{Eaton1988StoneAI,
  title={Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective.},
  author={Stanley Boyd Eaton and Melvin J. Konner and Marjorie Shostak},
  journal={The American journal of medicine},
  year={1988},
  volume={84 4},
  pages={
          739-49
        }
}
From a genetic standpoint, humans living today are Stone Age hunter-gatherers displaced through time to a world that differs from that for which our genetic constitution was selected. Unlike evolutionary maladaptation, our current discordance has little effect on reproductive success; rather it acts as a potent promoter of chronic illnesses: atherosclerosis, essential hypertension, many cancers, diabetes mellitus, and obesity among others. These diseases are the results of interaction between… Expand
Paleolithic nutrition: twenty-five years later.
  • M. Konner, S. Eaton
  • Medicine
  • Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2010
TLDR
In some respects, official recommendations today have targets closer to those prevalent among hunter-gatherers than did comparable recommendations 25 years ago, and doubts have been raised about the necessity for very low levels of protein, fat, and cholesterol intake common in official recommendations. Expand
How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
  • W. Kopp
  • Medicine
  • Diabetes, metabolic syndrome and obesity : targets and therapy
  • 2019
TLDR
It is suggested that the diet-related key changes in the developmental process include an increased production of reactive oxygen species and oxidative stress, development of hyperinsulinemia and insulin resistance, low-grade inflammation and an abnormal activation of the sympathetic nervous system and the renin-angiotensin system, all of which play pivotal roles in the development of diseases of civilization. Expand
WEIRD bodies: mismatch, medicine and missing diversity.
  • M. Gurven, D. Lieberman
  • Geography, Medicine
  • Evolution and human behavior : official journal of the Human Behavior and Evolution Society
  • 2020
TLDR
It is argued that preventing and treating chronic diseases of aging and other mismatch diseases will require both expanding study design to sample diverse populations and contexts, and fully incorporating evolutionary perspectives, to prevent and treat diseases. Expand
Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer.
TLDR
This review outlines the essence of the authors' hunter-gatherer genetic legacy and suggests practical steps to re-align their modern milieu with their ancient genome in an effort to improve cardiovascular health. Expand
A multidisciplinary reconstruction of Palaeolithic nutrition that holds promise for the prevention and treatment of diseases of civilisation
TLDR
The evidence for the long-reigning hypothesis of human evolution on the arid savanna is weighed against the hypothesis that man evolved in the proximity of water and the composition and merits of so-called 'Palaeolithic diets' are evaluated. Expand
The western diet and lifestyle and diseases of civilization
TLDR
It is proposed that the adoption of diet and lifestyle that mimic the beneficial characteristics of the preagricultural environment is an effective strategy to reduce the risk of chronic degenerative diseases. Expand
Thrifty genes for obesity and the metabolic syndrome — time to call off the search?
  • J. Speakman
  • Biology, Medicine
  • Diabetes & vascular disease research
  • 2006
TLDR
The evidence supporting the famine hypothesis is presented, details of the evidence supporting it are presented, and it is shown that this idea has five fundamental flaws. Expand
Origins and evolution of the Western diet: health implications for the 21st century.
TLDR
The evolutionary collision of the authors' ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization. Expand
The Human Life Course and the Biodemography of Aging NIH / NIA FOR 2004 -
Specific Aims Humans lived as hunter-gatherers for the vast majority of their evolutionary history (the genus Homo has existed for about 2 million years). Agriculture originated only 10,000 years agoExpand
Diet, evolution and aging
TLDR
It is shown that contemporary net acid-producing diets do indeed characteristically produce a low-grade systemic metabolic acidosis in otherwise healthy adult subjects, and that the degree of acidosis increases with age, in relation to the normally occurring age-related decline in renal functional capacity. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 105 REFERENCES
Antecedents of Cardiovascular Disease in Six Solomon Islands Societies
TLDR
The differences in serum cholesterol and uric acid levels, and in intrapopulation trends of blood pressure in relation to age between the more and less acculturated groups were found to correlate best with dietary differences, especially in intake of salt, and of tinned meat and fish. Expand
Diet, nutrition, and cancer.
TLDR
Studies conducted to date indicate that the modifying effect of diet and nutrition may be exerted through specific effects on 1) intestinal bacteria and substrates for bacterial metabolism, 2) microsomal mixed-function oxidase system, 3) endocrine system, 4) immunological system, 5) availability of metabolites for cell proliferation, and 6) rate of carcinogen transfer and duration of exposure to the carcinogen. Expand
DIABETES MELLITUS: A CONTRIBUTION TO ITS EPIDEMIOLOGY BASED CHIEFLY ON MORTALITY STATISTICS
TLDR
The essential and distinctive feature of epidemiology is the study or knowledge of that part of the natural history of a disease which determines its occurrence or distribution quantitatively and qualitatively in groups of persons. Expand
Diabetes in American Indians and Other Native Populations of the New World
TLDR
Research into the prevalence and manifestations of diabetes in aboriginal populations of the New World has considerable potential for gaining a better understanding of the genetic and environmental factors which influence risk and pathophysiology of diabetes and its complications. Expand
From normotension to hypertension in Kenyans and Ugandans 1928-1978.
TLDR
Diets comparable in many respects to the 1930 Kikuyu diet are suggested to reverse essential hypertension and should contain much unrefined high fiber high starch foods. Expand
From normotension to hypertension in Kenyans and Ugandans 1928-1978.
  • H. Trowell
  • Medicine
  • East African medical journal
  • 1980
TLDR
Field data in Kenya and Uganda suggest that blood pressure rises during adult life, and essential hypertension occurs in salt-sensitive individuals, when sodium chloride daily intake is excessive. Expand
Diabetes, blood lipids, lipoproteins, and change of environment: restudy of the "new immigrant Yemenites" in Israel.
TLDR
It appears that in newly discovered adult-onset diabetics in this population there is no shortage of insulin, but rather shortage of pancreatic insulin action. Expand
Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.
TLDR
The disease pattern of the Greenlanders differs from that of West-European populations, having a higher frequency of apoplexy and epilepsy but a lower frequency or absence of acute myocardial infarction, diabetes mellitus, thyrotoxicosis, bronchial asthma, multiple sclerosis and psoriasis. Expand
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.
TLDR
Evidence that the various common types of cancer are largely avoidable diseases is reviewed, and it is suggested that, apart from cancer of the respiratory tract, the types of cancers that are currently common are not peculiarly modern diseases and are likely to depend chiefly on some long-established factor. Expand
Physiologic and anthropometric parameters related to coronary risk factors in Yemenite Jews living different time spans in Israel.
TLDR
Observations demonstrate the development of certain coronary risk factors related to anthropometric and biochemical parameters in population groups exposed to the impact of Western-styled societies. Expand
...
1
2
3
4
5
...