Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligand.

@article{Snchez1999StoichiometryOT,
  title={Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligand.},
  author={Luis M. S{\'a}nchez and David M Penny and Pamela J. Bjorkman},
  journal={Biochemistry},
  year={1999},
  volume={38 29},
  pages={9471-6}
}
The neonatal Fc receptor (FcRn) transports immunoglobulin G (IgG) across epithelia, providing passive immunity and protecting serum IgG from degradation. For both functions, FcRn binds to IgG at the acidic pH of intracellular vesicles (pH </= 6.5) and releases IgG at the basic pH of the bloodstream (pH approximately 7.4). Crystallographic studies show that rat FcRn can interact with the Fc portion of IgG in a repeating array in which FcRn dimers are bridged by Fc fragments to create an… CONTINUE READING

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