Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics

@inproceedings{Smits2013StoichiometryOC,
  title={Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics},
  author={Arne H Smits and Pascal W.T.C. Jansen and Ina Poser and Anthony A. Hyman and Michiel Vermeulen},
  booktitle={Nucleic acids research},
  year={2013}
}
Many cellular proteins assemble into macromolecular protein complexes. The identification of protein-protein interactions and quantification of their stoichiometry is therefore crucial to understand the molecular function of protein complexes. Determining the stoichiometry of protein complexes is usually achieved by mass spectrometry-based methods that rely on introducing stable isotope-labeled reference peptides into the sample of interest. However, these approaches are laborious and not… CONTINUE READING

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