Stoichiometry of altered hERG1 channel gating by small molecule activators

@inproceedings{Wu2014StoichiometryOA,
  title={Stoichiometry of altered hERG1 channel gating by small molecule activators},
  author={Weiqiang Wu and Frank B. Sachse and Alison Gardner and Michael C Sanguinetti},
  booktitle={The Journal of general physiology},
  year={2014}
}
Voltage-gated K(+) channels are tetramers formed by coassembly of four identical or highly related subunits. All four subunits contribute to formation of the selectivity filter, the narrowest region of the channel pore which determines K(+) selective conductance. In some K(+) channels, the selectivity filter can undergo a conformational change to reduce K(+) flux by a mechanism called C-type inactivation. In human ether-a-go-go-related gene 1 (hERG1) K(+) channels, C-type inactivation is… CONTINUE READING
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