Stoichiometry of Nck-dependent actin polymerization in living cells

  title={Stoichiometry of Nck-dependent actin polymerization in living cells},
  author={Jonathon A. Ditlev and Paul J. Michalski and Greg Huber and Gonzalo M. Rivera and William Mohler and Leslie M. Loew and Bruce J Mayer},
  booktitle={The Journal of cell biology},
Regulation of actin dynamics through the Nck/N-WASp (neural Wiskott-Aldrich syndrome protein)/Arp2/3 pathway is essential for organogenesis, cell invasiveness, and pathogen infection. Although many of the proteins involved in this pathway are known, the detailed mechanism by which it functions remains undetermined. To examine the signaling mechanism, we used a two-pronged strategy involving computational modeling and quantitative experimentation. We developed predictions for Nck-dependent actin… CONTINUE READING
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