Stoichiometry and topology in protein folding.

  title={Stoichiometry and topology in protein folding.},
  author={Ruxandra I. Dima},
  journal={Journal of biomolecular structure & dynamics},
  volume={28 4},
  pages={617-8; discussion 669-674}
A fundamental piece of the puzzle, that is the protein folding problem, refers to the balance between energetic and topological frustration. Energetic frustration results from the often conflicting requirements that hydrophobic residues need to reside inside the folded protein structure, while polar and charged residues prefer to reside on the surface of the structure in close contact with water. Moreover, even if the energetic frustration for a particular protein sequence is substantially… CONTINUE READING

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