Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes.

  title={Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes.},
  author={Christopher V Kelly and Meghan Gaffney Liroff and L. Devon Triplett and Pascale R. Leroueil and Douglas G. Mullen and Joseph M Wallace and Sasha Meshinchi and James R Baker and Bradford G. Orr and Mark M Banaszak Holl},
  journal={ACS nano},
  volume={3 7},
The energetics, stoichiometry, and structure of poly(amidoamine) (PAMAM) dendrimer-phospholipid interactions were measured with isothermal titration calorimetry (ITC), transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS), and molecular dynamics (MD) simulations. Dendrimers of sixth-generation and smaller interacted with the lipids at an average stoichiometry and enthalpy proportional to the number of primary amines per dendrimers (4.5 ± 0.1… CONTINUE READING
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