Stochasticity and robustness analysis of microRNA-mediated ERK signaling network

@article{Zhou2018StochasticityAR,
  title={Stochasticity and robustness analysis of microRNA-mediated ERK signaling network},
  author={Wei Zhou and Ziyi Chen and Zhigang Liu and Yonghua Wang},
  journal={Computational biology and chemistry},
  year={2018},
  volume={76},
  pages={
          318-326
        }
}
MicroRNAs (miRNAs) play a critical role in regulating the signaling network such as the extracellular signal regulated kinase (ERK) pathway. However, the mechanisms of miRNA-mediated posttranscriptional regulations with regard to their impacts on signaling require further investigation from a systematic level. Therefore, we develop a mathematical model by analyzing the precise dynamic mechanisms with a bevy of miRNAs involved in the Ras/Raf/MEK/ERK pathway. A systems-based analysis approach is… CONTINUE READING