Stochastically Gating Ion Channels Enable Patterned Spike Firing through Activity-Dependent Modulation of Spike Probability

@article{Dudman2009StochasticallyGI,
  title={Stochastically Gating Ion Channels Enable Patterned Spike Firing
                    through Activity-Dependent Modulation of Spike Probability},
  author={Joshua Tate Dudman and Matthew F. Nolan},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={799 - 802}
}
The transformation of synaptic input into patterns of spike output is a fundamental operation that is determined by the particular complement of ion channels that a neuron expresses. Although it is well established that individual ion channel proteins make stochastic transitions between conducting and non-conducting states, most models of synaptic integration are deterministic, and relatively little is known about the functional consequences of interactions between stochastically gating ion… CONTINUE READING
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