Stochastic yet biased expression of multiple Dscam splice variants by individual cells

  title={Stochastic yet biased expression of multiple Dscam splice variants by individual cells},
  author={Guilherme Neves and Jacob P. Zucker and Mark Daly and Andrew Chess},
  journal={Nature Genetics},
The Drosophila melanogaster gene Dscam is essential for axon guidance and has 38,016 possible alternative splice forms. This diversity can potentially be used to distinguish cells. We analyzed the Dscam mRNA isoforms expressed by different cell types and individual cells. The choice of splice variants expressed is regulated both spatially and temporally. Different subtypes of photoreceptors express broad yet distinctive spectra of Dscam isoforms. Single-cell RT-PCR documented that individual… CONTINUE READING
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