Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia

  • Marek Kubickia, Jorge L. Alvaradoa, +9 authors Martha E. Shentona
  • Published 2011

Abstract

Background—Abnormalities within language-related anatomical structures have been associated with clinical symptoms and with language and memory deficits in schizophrenia. Recent studies suggest disruptions in functional connectivity within the Inferior Frontal Gyrus (IFG) network in schizophrenia. However, due to technical challenges, anatomical connectivity abnormalities within this network and their involvement in clinical and cognitive deficits have not been studied. Material and Methods—Diffusion and anatomical scans were obtained from 23 chronic schizophrenia patients and 23 matched controls. The IFG was automatically segmented, and its white matter connections extracted and measured with newly-developed stochastic tractography tools. Correlations between anatomical structures and measures of semantic processing were also performed. Results—White Matter connections between the IFG and posterior brain regions followed two distinct pathways: dorsal and ventral. Both demonstrated left lateralization, but ventral pathway abnormalities were only found in schizophrenia. IFG volumes also showed left lateralization and Corresponding Author: Marek Kubicki, MD, PhD; Psychiatry Neuroimaging Laboratory; 1249 Boylston Street, Boston, MA 02215; Tel: (617) 525-6234 Fax: (617) 525-6150, kubicki@bwh.harvard.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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@inproceedings{Kubickia2011StochasticTS, title={Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia}, author={Marek Kubickia and Jorge L. Alvaradoa and Carl-Fredrik Westinc and David F. Tated and Douglas Markanta and Douglas P. Terrya and Thomas J. Whitforda and Julien De Siebenthala and Sylvain Bouixa and Robert W. McCarleyb and Ron Kikinisg and Martha E. Shentona}, year={2011} }