Stochastic theory of large-scale enzyme-reaction networks: finite copy number corrections to rate equation models.

@article{Thomas2010StochasticTO,
  title={Stochastic theory of large-scale enzyme-reaction networks: finite copy number corrections to rate equation models.},
  author={Philipp Thomas and Arthur V. Straube and Ramon Grima},
  journal={The Journal of chemical physics},
  year={2010},
  volume={133 19},
  pages={
          195101
        }
}
Chemical reactions inside cells occur in compartment volumes in the range of atto- to femtoliters. Physiological concentrations realized in such small volumes imply low copy numbers of interacting molecules with the consequence of considerable fluctuations in the concentrations. In contrast, rate equation models are based on the implicit assumption of infinitely large numbers of interacting molecules, or equivalently, that reactions occur in infinite volumes at constant macroscopic… 

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