Stochastic switching to competence.

@article{Leisner2008StochasticST,
  title={Stochastic switching to competence.},
  author={Madeleine Leisner and Kerstin Stingl and Erwin Frey and Berenike Maier},
  journal={Current opinion in microbiology},
  year={2008},
  volume={11 6},
  pages={
          553-9
        }
}
Distinct modes of gene expression enable isogenic populations of bacteria to maintain a diversity of phenotypes and to rapidly adapt to environmental changes. Competence development for DNA transformation in Bacillus subtilis has become a paradigm for a multimodal system which implements a genetic switch through a nonlinear positive feedback of a transcriptional master regulator. Recent advances in quantitative analysis at the single cell level in conjunction with mathematical modeling allowed… CONTINUE READING

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