Stochastic protein expression in individual cells at the single molecule level

@article{Cai2006StochasticPE,
  title={Stochastic protein expression in individual cells at the single molecule level},
  author={Long Cai and Nir Friedman and Xiaoliang Sunney Xie},
  journal={Nature},
  year={2006},
  volume={440},
  pages={358-362}
}
In a living cell, gene expression—the transcription of DNA to messenger RNA followed by translation to protein—occurs stochastically, as a consequence of the low copy number of DNA and mRNA molecules involved. These stochastic events of protein production are difficult to observe directly with measurements on large ensembles of cells owing to lack of synchronization among cells. Measurements so far on single cells lack the sensitivity to resolve individual events of protein production. Here we… CONTINUE READING
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