Stochastic modeling for the COMET-assay

Abstract

We present a stochastic model for single cell gel electrophoresis (COMET-assay) data. The distribution of length of DNA fragments is calculated according to a ’Random Breakage Model’ and the migration of DNA fragments among gel fibers is discussed. Essential to our approach is the use of point process structures, renewal theory and reduction to intensity histograms for further data analysis. Parameter estimations and simulations illustrate the features of the model.

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Cite this paper

@inproceedings{Boulesteix2003StochasticMF, title={Stochastic modeling for the COMET-assay}, author={A.-L. Boulesteix and V. H{\"{o}sel and V. Liebscher}, year={2003} }