Stochastic model-assisted development of efficient low-dose viral transduction in microfluidics.

Abstract

Adenoviruses are commonly used in vitro as gene transfer vectors in multiple applications. Nevertheless, issues such as low infection efficiency and toxicity effects on host cells have not been resolved yet. This work aims at developing a new versatile tool to enhance the expression of transduced genes while working at low viral doses in a sequential manner… (More)
DOI: 10.1016/j.bpj.2012.12.049

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