Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases.

@article{Germain2015StochasticIO,
  title={Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases.},
  author={Elsa Germain and Mohammad Roghanian and Kenn Gerdes and Etienne Maisonneuve},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 16},
  pages={
          5171-6
        }
}
The model organism Escherichia coli codes for at least 11 type II toxin-antitoxin (TA) modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode messenger RNA endonucleases (mRNases) inhibiting translation by catalytic degradation of mRNA, and the 11th module, hipBA, encodes HipA (high persister protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX). In turn, inhibition of GltX inhibits translation and induces the stringent response and persistence… CONTINUE READING

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